177985-33-0 | 2-CHLORO-5-FLUOROPHENYLACETIC ACID

CAS:177985-33-0 | 2-CHLORO-5-FLUOROPHENYLACETIC ACID,Description

Synthesis Analysis

2-Chloro-5-fluorophenylacetic acid can be synthesized through a multi-step process involving amidation, etherification, Smiles rearrangement, chloroacetylation, cyclization, and hydrolysis. A specific example includes the synthesis of 2-{[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid from p-Methylaniline and chloroacetic chloride, showcasing a methodological approach to obtaining halogenated phenylacetic acid derivatives with an overall yield of 66% (Liu Ying-xiang, 2007).

Safety And Hazards

The safety information for “2-Chloro-5-fluorophenylacetic acid” indicates that it may be harmful if swallowed (Hazard Statements H302). Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray and using only outdoors or in a well-ventilated area.

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